Rare bleeding disorders
https://doi.org/10.21682/2311-1267-2020-7-3-54-63
Abstract
Rare bleeding disorders include inherited deficiencies of fibrinogen, factors (F) II, FV, FVII, FX, FXI, FXII, and FV + FVIII, as well as a multiple deficiency of vitamin K-dependent coagulation factors. Some of these deficiencies are more studied, due to the large number of patients, some are extremely rare, so at this stage it is quite difficult for them to develop a universal approach to therapy and prophylactic treatment. The purpose of this review was to evaluate the frequency, clinical manifestations, genetic basis, possibilities and difficulties of diagnosis for these deficiencies.
About the Authors
D. B. Florinskiy
Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology, Ministry of Health of Russia
Russian Federation
Russian Federation
Resident in Pediatrics
1 Samory Mashela St., Moscow, 117997
P. A. Zharkov
Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology, Ministry of Health of Russia
Russian Federation
Russian Federation
Dr. of Sci. (Med.), Hematologist Advisory Unit, Short-Term Hospital Pediatrician, Head of the Hemostasis Research Group
1 Samory Mashela St., Moscow, 117997
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Review
For citations:
Florinskiy D.B., Zharkov P.A. Rare bleeding disorders. Russian Journal of Pediatric Hematology and Oncology. 2020;7(3):54-63. (In Russ.) https://doi.org/10.21682/2311-1267-2020-7-3-54-63
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