Nephrogenic rests and nephroblastomatosis: literature review and clinical reports
https://doi.org/10.21682/2311-1267-2020-7-3-119-124
Abstract
Nephrogenic rests and nephroblastomatosis describe persistence of embryonic renal parenchyma (metanephric blastema) beyond 36 weeks of gestation, when nephrogenesis is normally complete. This persistent metanephric blastema may transform into the Wilms tumor, and are detected in 30–40 % of unilateral nephroblstoma and nearly 100 % in bilateral cases. The risk of Wilms tumour is increased in any type of nephrogenic rests/nephroblastomatosis but it is higher in infants and in patients with intralobar nephrogenic rests. We cite below several studies described different types of nephrogenic rests, their connection with nephroblastoma development and the details of diagnostic. We refer to clinical examples, in that regard. Two cases are presented: bilateral diffuse hyperplastic perilobar nephroblastomatosis in one child and an infant with combination of perilobar nephrogenic rests in one kidney and Wilms tumour in the other kidney.
About the Authors
L. I. Shats
Saint-Petersburg State Pediatric Medical University, Ministry of Health of Russia;
Saint Petersburg Clinical Scientific and Practical Center of Specialized Medical Assistance (Oncological)
Russian Federation
Russian Federation
Pediatric Oncologist, Assistant at the Department of Oncology, Pediatric Oncology and Radiotherapy at theSt. PetersburgStatePediatricMedicalUniversity
2 Litovskaya St., S.-Petersburg, 19410,
68А Leningradskaya St., Pesochny, S.-Petersburg, 197758
B. V. Kondratiev
MRI Center Moskovskaya
Russian Federation
Russian Federation
Radiologist
12A Tipanova St., S.-Petersburg, 196135
M. B. Belogurova
Saint-Petersburg State Pediatric Medical University, Ministry of Health of Russia;
Saint Petersburg Clinical Scientific and Practical Center of Specialized Medical Assistance (Oncological)
Russian Federation
Russian Federation
Dr. of Sci. (Med.), Professor, Head of the Department of Oncology, Pediatric Oncology and Radiotherapy at theSt. PetersburgStatePediatricMedicalUniversity, Head of Children’s Oncology Department at the Saint Petersburg Clinical Scientific and Practical Center of Specialized Medical Assistance (Oncological)
2 Litovskaya St., S.-Petersburg, 19410,
68А Leningradskaya St., Pesochny, S.-Petersburg, 197758
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Review
For citations:
Shats L.I., Kondratiev B.V., Belogurova M.B. Nephrogenic rests and nephroblastomatosis: literature review and clinical reports. Russian Journal of Pediatric Hematology and Oncology. 2020;7(3):119-124. (In Russ.) https://doi.org/10.21682/2311-1267-2020-7-3-119-124
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