Preview

Russian Journal of Pediatric Hematology and Oncology

Advanced search

Atypical presentation of metastatic disease in patients with stage 4S neuroblastoma of the observation group: description of the clinical case

https://doi.org/10.21682/2311-1267-2020-7-3-125-131

Abstract

The most common extracranial solid malignant tumor of childhood – neuroblastoma (NB) is characterized by the presence of two metastatic forms (stages 4 and 4S). Stage 4S is described to have metastatic spread to the liver, skin, and minimal bone marrow invasion. Certain rare localisations of NB metastases (pleura, testicles, and others) may not worsen the prognosis in children of the first year of life in the absence of severe bone marrow invasion and metastases to the skeletal bones. The article describes a clinical case of retroperitoneal NB with atypical metastasis to the pleura in a child of the first months of life with a favorable outcome with a minimum amount of chemotherapy.

About the Authors

L. A. Smirnova
Dmitry Rogachev National Research Center of Pediatric Hematology, Oncology and Immunology, Ministry of Health of Russia
Russian Federation

Resident in the Specialty “Children's Oncology”

1 Samory Mashela St., Moscow, 117997



D. Yu. Kachanov
Dmitry Rogachev National Research Center of Pediatric Hematology, Oncology and Immunology, Ministry of Health of Russia
Russian Federation

Dr. of Sci. (Med.), Head of the Department of Clinical Oncology, Deputy Director of the Institute of Oncology, Radiology and Nuclear Medicine

1 Samory Mashela St., Moscow, 117997

SPIN-code: 9878-5540



A. P. Shcherbakov
Dmitry Rogachev National Research Center of Pediatric Hematology, Oncology and Immunology, Ministry of Health of Russia
Russian Federation

Physician of Radiology Department

1 Samory Mashela St., Moscow, 117997



D. G. Akhaladze
Dmitry Rogachev National Research Center of Pediatric Hematology, Oncology and Immunology, Ministry of Health of Russia
Russian Federation

Cand. of Sci. (Med.), Head of Thoracoabdominal Surgery Group

1 Samory Mashela St., Moscow, 117997



M. V. Teleshova
Dmitry Rogachev National Research Center of Pediatric Hematology, Oncology and Immunology, Ministry of Health of Russia
Russian Federation

Pediatric Oncologist Department of Clinical Oncology

1 Samory Mashela St., Moscow, 117997



Yu. N. Likar
Dmitry Rogachev National Research Center of Pediatric Hematology, Oncology and Immunology, Ministry of Health of Russia
Russian Federation

Dr. of Sci. (Med.), Head of Positron Emission Tomography and Radionuclide Diagnostics Department

1 Samory Mashela St., Moscow, 117997



T. V. Shamanskaya
Dmitry Rogachev National Research Center of Pediatric Hematology, Oncology and Immunology, Ministry of Health of Russia
Russian Federation

Cand. of Sci. (Med.), Head of the Department of Embryonic Tumors Research of the Institute of Oncology, Radiology and Nuclear Medicine

1 Samory Mashela St., Moscow, 117997



References

1. Shamanskaya T.V., Kachanov D.Yu., Feoktistova E.V., Tereshchenko G.V., Likar Yu.N., Muftakhova G.M., Talypov S.R., Varfolomeeva S.R. Heterogeneity of neuroblastoma stage 4S: a multidisciplinary view. Rossiyskiy zhurnal detskoy gematologii i onkologii = Russian Journal of Pediatric Hematology and Oncology 2017;4(1):83–8. (In Russ.). doi: 10.17650/2311-1267-2017-4-1-83-88.

2. Brodeur G.M., Pritchard J., Berthold F., Carlsen N.L., Castel V., Castleberry R.P., Bernardi B.D., Evans A. E., Favrot M.C., Hedborg F., Kaneko M., Kemshead J., Lampert F., Lee R.J., Look A.T., Pearson A.D., Philip T., Roald B., Sawada T., Seeger R.C., Tsuchida Y., Voute P.A. Revisions of the international criteria for neuroblastoma diagnosis, staging, and response to treatment. J Clin Oncol 1993;11(8):1466–77. doi: 10.1200/JCO.1993.11.8.1466.

3. Pritchard J., Hickman J.A. Why does stage 4s neuroblastoma regress spontaneously? Lancet 1994;344(8926):869–70. doi: 10.1016/S0140-6736(94)92834-7.

4. van Noesel M.M., Hählen K., Hakvoort-Cammel F.G., Egeler R.M. Neuroblastoma 4S: a heterogeneous disease with variable risk factors and treatment strategies. Cancer 1997;80(5):834–43. PMID: 9307181.

5. Monclair T., Brodeur G.M., Ambros P.F., Brisse H.J., Cecchetto G., Holmes K., Kaneko M., London W.B., Matthay K.K., Nuchtern J.G., von Schweinitz D., Simon T., Cohn S.L., Pearson A.D.J.; INRG Task Force. The International Neuroblastoma Risk Group (INRG) staging system: an INRG Task Force report. J Clin Oncol 2009;27(2):298–303. doi: 10.1200/JCO.2008.16.6876.

6. Pepper W.A. A study of congenital sarcoma of the liver and suprarenal with report of a case. Am J Med Sci 1901;121(3):287.

7. Rothenberg A.B., Berdon W.E., D’Angio G.J., Yamashiro D.J., Cowles R.A. Neuroblastoma-remembering the three physicians who described it a century ago: James Homer Wright, William Pepper, and Robert Hutchison. Pediatr Radiol 2009;39(2):155–60. doi: 10.1007/s00247-008-1062-z.

8. Kachanov D.Yu., Shamanskaya T.V., Muftakhova G.M., Varfolomeeva S.R. Neuroblastoma stage 4S. Voprosy gematologii/onkologii i immunopatologii v pediatrii = Pediatric Hematology/Oncology and Immunopathology 2014;13(2):9–19. (In Russ.).

9. Hero B., Simon T., Horz S., Berthold F. Metastatic neuroblastoma in infancy: What does the pattern of metastases contribute to prognosis? Med Pediatr Oncol 2000;35:683–7. doi: 10.1002/1096-911x(20001201)35:6<683::aid-mpo43>3.0.co;2-f.

10. Simon T., Hero B., Schulte J.H., Deubzer H., Hundsdoerfer P., von Schweinitz D., Fuchs J., Schmidt M., Prasad V., Krug B., Timmermann B., Leuschner I., Fischer M., Langer T., Astrahantseff K., Berthold F., Lode H., Eggert A. 2017 GPOH Guidelines for Diagnosis and Treatment of Patients with Neuroblastic Tumors. Klin Pädiatr 2017;229(3):147–67. doi:10.1055/s-0043-103086.

11. Simon T., Hero B., Berthold F. Testicular and paratesticular involvement by metastatic neuroblastoma. Cancer 2000;88(11):2636–41. doi: 10.1002/1097-0142(20000601)88:11<2636:AID-CNCR28>3.0.CO;2-K.

12. Moser O., Scheurlen W., Leipold A., Dilloo D., Hero B. Muscle involvement in neuroblastoma with spontaneous regression. Proceedings of Advances in Neuroblastoma Research Congress. 13–16 May 2014. Cologne, Germany. Abstr. POC024. Pp. 237–238.

13. Meyers P.A., Heller G., Healey J.H., Huvos A., Applewhite A., Sun M., LaQuaglia M. Osteogenic sarcoma with clinically detectable metastasis at initial presentation. J Clin Oncol 1993;11(3):449–53. doi: 10.1200/jco.1993.11.3.449.

14. Zhilkin I.V., Akhaladze D.G., Litvinov D.V., Uskova N.G., Tikhonova M.V., Grachev N.S., Karachunskiy A.I. Metastatic lung disease in osteosarcoma. Voprosy gematologii/onkologii i immunopatologii v pediatrii = Pediatric Hematology/Oncology and Immunopathology 2019;18(4):127–35. (In Russ.). doi: 10.24287/1726-1708-2019-18-4-127-135.

15. Bosma S.E., Rueten‐Budde A.J., Lancia C., Ranft A., Dirksen U., Krol A.D., Gelderblom H., van de Sande M., Dijkstra P., Fiocco M. Individual risk evaluation for local recurrence and distant metastasis in Ewing sarcoma: A multistate model for Ewing sarcoma. Pediatr Blood Cancer 2019;66(11):e27943. doi: 10.1002/pbc.27943.


Review

For citations:


Smirnova L.A., Kachanov D.Yu., Shcherbakov A.P., Akhaladze D.G., Teleshova M.V., Likar Yu.N., Shamanskaya T.V. Atypical presentation of metastatic disease in patients with stage 4S neuroblastoma of the observation group: description of the clinical case. Russian Journal of Pediatric Hematology and Oncology. 2020;7(3):125-131. (In Russ.) https://doi.org/10.21682/2311-1267-2020-7-3-125-131

Views: 506


Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.


ISSN 2311-1267 (Print)
ISSN 2413-5496 (Online)
X