Development strategy of the registry of donors of hematopoietic stem cells
https://doi.org/10.21682/2311-1267-2020-7-4-35-42
Abstract
Aim of the study — to develop a strategy for the recruiting potential donors to the registry, which is based on the biological characteristics of russian populations.
Materials and methods. The object of the study was 35,117 potential donors of the hematopoietic stem cells of the registry of KRIHBT FMBA of Russia, recruited in 22 subjects of the Russian Federation.
Results. Based on a comparison of the HLA-A-B-C-DRB1 haplotype profiles of local donor populations, calculated using the EM-algorithm in the Arlequin v.3.5.2.2 software, with the profile of the pooled donor population of the registry, general requirements for the recruitment of potential hematopoietic stem cells donors to the registry were formulated.
About the Authors
M. A. Loginova
Kirov Research Institute of Hematology and Blood Transfusion of the Federal Medical and Biological Agency of Russia
Russian Federation
Russian Federation
Cand. of Sci. (Biol.), Head of the Research Laboratory of Applied Immunogenetics at Kirov Research Institute of Hematology and Blood.
72 Krasnoarmeyskaya St., Kirov, 610027.
I. V. Paramonov
Kirov Research Institute of Hematology and Blood Transfusion of the Federal Medical and Biological Agency of Russia
Russian Federation
Russian Federation
Dr. of Sci. (Med.), Director of Kirov Research Institute of Hematology and Blood Transfusion of the Federal Medical and Biological Agency of Russia.
72 Krasnoarmeyskaya St., Kirov, 610027.
References
1. Malignant neoplasms in Russia in 2015 (morbidity and mortality). Edited by A.D. Kaprin, V.V. Starinsky, G.V. Petrova. M.: MNIOI im. P.A. Herzen - branch of the FSBI “NMRRC” of the Ministry of Health of Russia, 2017. 250 p. (In Russ.).
2. Startseva A.Yu., Yanushevskaya E.A., Uss A.L., Krivenko S.I. Practical aspects of donor selection for unrelated transplantation of hematopoietic stem cells. Problemy zdorov'ya i ekologii = Health and Ecology Problems 2011;S:83-5. (In Russ.).
3. Hematopoietic Stem Cell Transplantation. A Handbook for Clinicians. Edit by Wingard J.R., Gastineau D.A., Leather H.L. BPharm, Snyder E., FACP MD, FCAP. 2nd edition. Maryland: AABB, 2015. 970 p.
4. Gritsaev S.V., Pavlova I.E., Semenova N.Yu. Selected aspects of hematopoietic stem cell transplantation in oncohematological patients (lecture). Vestnik gematologii = Hematology Bulletin 2015;XI(3):1-20. (In Russ.).
5. Pop V.P., Rukavitsyn O.A. Allogeneic hematopoietic stem cell transplantation: perspectives and alternatives, own experience. Rossijskij zhurnal detskoj gematologii i onkologii = Russian Journal of Pediatric Hematology and Oncology 2017;4:46-69. (In Russ.).
6. Skvortsova Yu.V., Shelikhova L.N., Myakova N.V., Biyachuev E.R., Konovalov D.M., Abramov D.S., Maschan M.A., Skorobogatova E.V., Rumyantsev A.G., Maschan A.A. Lymphoid neoplasia after allogeneic hematopoietic stem cell transplantation. A case of secondary Hodgkin's lymphoma, differential diagnosis with post-transplant lymphoproliferative disease. Onkogematologiya = Oncohematology 2017;1 (2):54-61. (In Russ.).
7. HLA Alleles Numbers [Electronic resource]: http://hla.alleles.org/nomenclature/stats.html (appeal date 05.11.2020).
8. WMDA Database. [Electronic resource]: https://share.wmda.info/display/WMDAREG/Database#/ (appeal date 04.11.2020).
9. Evseeva I., Foeken L., Madrigal A. The Role of Unrelated Donor Registries in HSCT. In: The EBMT Handbook. Hematopoietic Stem Cell Transplantation and Cellular Therapies. Eds. E. Carreras, C. Dufour, M. Mohty, N. Kroger. Switzerland: Springer Nature, 2019. P. 19-25.
10. Population of Russia: number, dynamics, statistics [Electronic resource]: http://www.statdata.ru/russia (appeal date 04.11.2020). (In Russ.).
11. Excoffier L., Slatkin M. Maximum-likelihood estimation of molecular haplotype frequencies in a diploid population. Mol Biol Evol 1995;12(5):921-7. doi: 10.1093/oxfordjournals.molbev.a040269.
12. Excoffier L., Laval G., Schneider S. Arlequin (version 3.0): An integrated software package for population genetics data analysis. Evolutionary Bioinformatics Online 2005;1:47-50.
13. Boldyreva M.N., Guskova I.A., Bogatova O.V., Yankevich T.E., Khromova N.A., Tegako O.V., Ashramentova L.A., Ischuk M.V., Dubova N A.A., Ganicheva L.L., Pozdeeva O.S., Balanovskaya E.V., Alekseev L.P. HLA-genetic diversity of the population of Russia and the CIS. II. Peoples of the European part. Immunologiya = Immunology 2006;4:198-202. (In Russ.).
14. Pozdeeva O.S., Boldyreva M.N., Yankevich T.E., Alekseev L.P. Class II histocompatibility genes in the Udmurt population. Immunologiya = Immunology 2014;2:60-3. (In Russ.).
Review
For citations:
Loginova M.A., Paramonov I.V. Development strategy of the registry of donors of hematopoietic stem cells. Russian Journal of Pediatric Hematology and Oncology. 2020;7(4):35-42. (In Russ.) https://doi.org/10.21682/2311-1267-2020-7-4-35-42
Views:
507
Email this article 