Primary central nervous system lymphomas in children and adolescents
Abstract
Primary central nervous system lymphomas (PCNSL) are very rare and one of the most aggressive variants of extranodal nonHodgkin’s lymphomas (NHL). PCNSL comprise from 4 to 7 % of malignant tumors of the central nervous system in adults, and their true frequency in children is unknown. In the last few decades, the frequency of PCNSL has been increasing, possibly due to an increase the number of people with primary and secondary immunodeficiencies, although PCNSL are also diagnosed in people without an immunodeficiency condition. Due to the rare occurrence of PCNSL in children and adolescents, the clinical and morphoimmunological features of this extranodal variant of NHL need to be generalized and systematized. No less important problem is the choice of therapeutic tactics for PCNSL therapy in children. Current review presents the world and domestic experience in the diagnosis and treatment of pediatric and adolescent PCNSL.
About the Authors
T. Yu. Pavlova
N.N. Blokhin National Medical Research Centre of Oncology, Ministry of Health of Russia
Russian Federation
Russian Federation
Pediatric Oncologist Children’s Department of Hemoblastosis Chemotherapy of the Department of Hematology and Bone Marrow Transplantation of Research Institute of Pediatric Oncology and Hematology,
23 Kashirskoe shosse, Moscow, 115478
T. T. Valiev
N.N. Blokhin National Medical Research Centre of Oncology, Ministry of Health of Russia
Russian Federation
Russian Federation
Dr. of Sci. (Med.), Head of the Children’s Department of Hemoblastosis Chemotherapy of the Department of Hematology and Bone Marrow Transplantation of Research Institute of Pediatric Oncology and Hematology,
23 Kashirskoe shosse, Moscow, 115478
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Pavlova T.Yu., Valiev T.T. Primary central nervous system lymphomas in children and adolescents. Russian Journal of Pediatric Hematology and Oncology. 2021;8(1):43-49. (In Russ.)
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