The use of proton radiation therapy in a patient with melanotic neuroectodermal tumor of infants of the anterior fontanel: description of a clinical case
N. D. Faseeva,
N. I. Martynova,
M. D. Maksimov,
K. F. Boyko,
N. A. Vorobyev,
N. A. Berezina,
N. A. Plakhotina,
D. A. Reshchikov,
I. G. Vasiliev,
R. B. Mai,
M. A. Titova,
O. G. Zheludkova https://doi.org/10.21682/2311-1267-2022-9-1-60-66
Abstract
Melanotic neuroectodermal tumor (MNET) of infants is a rare benign neoplasm detected mainly in children of the first year of life. Standard therapy consists of radical surgical removal of the tumor. Currently, the treatment of patients with recurrent and unresectable forms of the disease is relevant. The number of publications using polychemotherapy and radiation therapy is extremely limited. This article describes a clinical case of the occurrence of MNET in the anterior fontanel with a recurrent course. Proton radiation therapy was chosen as an alternative treatment method.
About the Authors
N. D. Faseeva
DTC IIBS named after S. Berezin
Russian Federation
Russian Federation
Cand. of Sci. (Med.), Pediatric Oncologist Department of Pediatric Oncology
Saint-Petersburg
N. I. Martynova
DTC IIBS named after S. Berezin
Russian Federation
Russian Federation
Radiation Therapist Clinics Radiosurgery, Stereotactic Radiotherapy and General Oncology
Saint-Petersburg
M. D. Maksimov
DTC IIBS named after S. Berezin
Russian Federation
Russian Federation
Trainee-doctor
Saint-Petersburg
K. F. Boyko
DTC IIBS named after S. Berezin
Russian Federation
Russian Federation
Pediatric Oncologist, Head of the Department of Pediatric Oncology
Saint-Petersburg
N. A. Vorobyev
DTC IIBS named after S. Berezin; Saint-Petersburg State University; North-Western State Medical University named after I.I. Mechnikov, Ministry of Health of Russia
Russian Federation
Russian Federation
Cand. of Sci. (Med.), Radiation Therapist, Head of the Department Proton Radiotherapy; Assistant Professor Department of Oncology; Assistant Professor Department of Oncology
Saint-Petersburg
N. A. Berezina
DTC IIBS named after S. Berezin
Russian Federation
Russian Federation
Cand. of Sci. (Med.), Radiologist Head Doctor
Saint-Petersburg
N. A. Plakhotina
DTC IIBS named after S. Berezin
Russian Federation
Russian Federation
Cand. of Sci. (Med.), Radiologist
Saint-Petersburg
D. A. Reshchikov
Russian Children’s Clinical Hospital of the N.I. Pirogov Russian National Research Medical University, Ministry of Health of Russia
Russian Federation
Russian Federation
Neurosurgeon
Moscow
I. G. Vasiliev
Russian Children’s Clinical Hospital of the N.I. Pirogov Russian National Research Medical University, Ministry of Health of Russia
Russian Federation
Russian Federation
Neurosurgeon
Moscow
R. B. Mai
Russian Children’s Clinical Hospital of the N.I. Pirogov Russian National Research Medical University, Ministry of Health of Russia
Russian Federation
Russian Federation
Neurosurgeon
Moscow
M. A. Titova
Saint-Petersburg State Pediatric Medical University, Ministry of Health of Russia
Russian Federation
Russian Federation
Resident
Saint-Petersburg
O. G. Zheludkova
DTC IIBS named after S. Berezin; Scientific and Practical Center for Specialized Medical Care for Children named after V.F. Voyno-Yasenetsky Moscow Healthcare Department
Russian Federation
Russian Federation
Dr. of Sci. (Med.), Professor, Expert of the Higher Attestation Commission on Pediatric Neuro-Oncology, Pediatric Oncologist
Saint-Petersburg
Moscow
References
1. Rachidi S., Sood A.J., Patel K.G., Nguyen S.A., Hamilton H., Neville B.W., Day T.A. Melanotic Neuroectodermal Tumor of Infancy: A Systematic Review. J Oral Maxillofac Surg. 2015;73(10):1946–56. PMID: 25936939. doi: 10.1016/j.joms.2015.03.061.
2. Piperi E.P., Rake S.A., Tosios K.I., Vasilopoulou E.E., Rake A.P., Sandler N.A., Issacson T., Sklavounou A., Koutlas I.G. Mandibular Melanotic Neuroectodermal Tumor of Infancy Treated Conservatively With Enucleation. J Craniofac Surg. 2010;21(3):685–8. PMID: 20485029. doi: 10.1097/SCS.0b013e3181d7f0c5.
3. Chillal M., Menon S., Archana S., Sham M.E. Melanotic neuroectodermal tumor of infancy of maxilla: Report of a case with review of literature. J Oral Maxillofac Pathol. 2021;25(2):351–5. PMID: 34703132. doi: 10.4103/0973-029X.325239.
4. Derache A.F., Rocourt N., Delattre C., Vinchon M., Orbach D., Leblond P. Les tumeurs neuroectodermiques mélanotiques infantiles: état actuel des connaissances. Bull Cancer. 2014;101:626–36. PMID: 24977451. doi: 10.1684/bdc.2014.1985.
5. Suleymanova A.M., Ozerov S.S., Roshchin V.Yu., Grachev N.S., Bolshakov N.A., Druy A.E., Tereshchenko G.V., Konovalov D.M., Sagoyan G.B., Shamanskaya T.V., Kachanov D.Yu., Varfolomeeva S.R. Melanotic neuroectodermal tumor of infancy: a description of the experience of Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology and literature review. Rossiyskiy zhurnal detskoy gematologii i onkologii. = Russian Journal of Pediatric Hematology and Oncology. 2019;6(3):44–53. (In Russ.).
6. Soles B.S., Wilson A., Lucas D.R., Heider A. Melanotic Neuroectodermal Tumor of Infancy. Arch Pathol Lab Med. 2018;142(11):1358–63. PMID: 30407852. doi: 10.5858/arpa.2018-0241-RA.
7. Franchi G., Sleilati F., Soupre V., Boudjemaa S., Josset P., Diner P.A., Vazquez M.P. Melanotic neuroectodermal tumour of infancy involving the orbit and maxilla: surgical management and follow-up strategy. Br J Plast Surg. 2002;55(6):526–9. PMID: 12479433. doi: 10.1054/bjps.2002.3910.
8. Fowler D.J., Chisholm J., Roebuck D., Newman L., Malone M., Sebire N.J. Melanotic Neuroectodermal tumor of infancy: clinical, radiological, and pathological features. Fetal Pediatr Pathol. 2006;25(2):59–72. PMID: 16908456. doi: 10.1080/15513810600788715.
9. Haque S., McCarville M.B., Sebire N., McHugh K. Melanotic neuroectodermal tumour of infancy: CT and MR fi ndings. Pediatr Radiol. 2012;42(6):699–705. PMID: 22430481. doi: 10.1007/s00247-011-2339-1.
10. Chrcanovic B.R., Gomez R.S. Melanotic neuroectodermal tumour of infancy of the jaws: an analysis of diagnostic features and treatment. Int J Oral Maxillofac Surg. 2018;48(1):1–8. PMID: 30170777. doi: 10.1016/j.ijom.2018.08.006.
11. Manojlovic S., Virag M., Luksic I., Muller D. Melanotic neuroectodermal tumour of infancy: report of two cases and review of the literature. J Craniomaxillofac Surg. 2012;40(4):e103–7. PMID: 21737290. doi: 10.1016/j.jcms.2011.05.013.
12. Kumari T.P., Venugopal M., Mathews A., Kusumakumary P. Effectiveness of chemotherapy in melanotic neurectodermal tumor of infancy. Pediatr Hematol Oncol. 2005;22(3):199–206. doi: 10.1080/08880010590921450.
13. Emmerling M.R., York T.A., Caccamese J.F. Melanotic Neuroectodermal Tumor of Infancy: Case Report and Review of Management. J Oral Maxillofac Surg. 2019;77(2):315–20. doi: 10.1016/j.joms.2018.09.033.
Review
For citations:
Faseeva N.D., Martynova N.I., Maksimov M.D., Boyko K.F., Vorobyev N.A., Berezina N.A., Plakhotina N.A., Reshchikov D.A., Vasiliev I.G., Mai R.B., Titova M.A., Zheludkova O.G. The use of proton radiation therapy in a patient with melanotic neuroectodermal tumor of infants of the anterior fontanel: description of a clinical case. Russian Journal of Pediatric Hematology and Oncology. 2022;9(1):60-66. (In Russ.) https://doi.org/10.21682/2311-1267-2022-9-1-60-66
Views:
678
Email this article 