Clinical case of long-term persistence of SARS-CoV-2 in infant with congenital acute myeloid leukemia
D. O. Ivanov,
G. V. Kondratiev,
M. E. Melnikov,
S. L. Bannova,
S. A. Kuleva,
Yu. V. Petrenko,
V. N. Timchenko,
V. A. Reznik https://doi.org/10.21682/2311-1267-2022-9-3-99-106
Abstract
According to the available data, children are less susceptible for developing a severe course of COVID-19 and commonly have mild or asymptomatic course of infection. It is reported about an increased risk of having more severe course in infants, at the same time, according to the literature data, the course in children receiving antineoplastic and immunosuppressive therapy is milder in comparison with other concomitant pathologies. This article presents the unique clinical case and the literature review of combined COVID-19-pneumonia and extremely rare congenital myeloid leukemia in the infant with the description of long-term infection persistence, changes in clinical data in dynamics, bone marrow test results and the experience of using donor plasma with antibodies to SARS-CoV-2.
About the Authors
D. O. Ivanov
Saint-Petersburg State Pediatric Medical University, Ministry of Health of Russia
Russian Federation
Russian Federation
Dr. of Sci. (Med.), Professor, Honored Doctor of the Russian Federation, Chief Freelance Specialist Neonatologist of the Ministry of Health of Russia, Rector. SPIN-code: 4437-9626
2 Litovskaya St., S.-Petersburg, 194100
G. V. Kondratiev
Saint-Petersburg State Pediatric Medical University, Ministry of Health of Russia
Russian Federation
Russian Federation
Assistant Department of Oncology, Pediatric Oncology and Radiation Therapy, Pediatric Oncologist. SPIN-code: 9092-3185
2 Litovskaya St., S.-Petersburg, 194100
M. E. Melnikov
Saint-Petersburg State Pediatric Medical University, Ministry of Health of Russia
Russian Federation
Russian Federation
5th year Student of Pediatrics Faculty, Laboratory Assistant Department of Oncology, Pediatric Oncology and Radiation Therapy
2 Litovskaya St., S.-Petersburg, 194100
S. L. Bannova
Saint-Petersburg State Pediatric Medical University, Ministry of Health of Russia
Russian Federation
Russian Federation
Cand. of Sci. (Med.), Associate Professor Department of Infectious Diseases in Children named after professor M.G. Danilevich. SPIN-code: 9654-9386
2 Litovskaya St., S.-Petersburg, 194100
S. A. Kuleva
Saint-Petersburg State Pediatric Medical University, Ministry of Health of Russia; N.N. Petrov National Medical Research Center of Oncology, Ministry of Health of Russia
Russian Federation
Russian Federation
Dr. of Sci. (Med.), Professor, Head of the Department of Oncology, Pediatric Oncology and Radiation Therapy; Head of Pediatric Oncology Department, Leading Researcher of the Research Department of Innovative Therapeutic Oncology and Rehabilitation Methods, Professor of the Training and Methodology Department. SPIN-code: 3441-4820
2 Litovskaya St., S.-Petersburg, 194100
68 Leningradskaya St., Pesochny, S.-Petersburg, 197758
Yu. V. Petrenko
Saint-Petersburg State Pediatric Medical University, Ministry of Health of Russia
Russian Federation
Russian Federation
Cand. of Sci. (Med.), Vice-Rector for National Projects and Clinical Work. SPIN-code: 1644-1394
2 Litovskaya St., S.-Petersburg, 194100
V. N. Timchenko
Saint-Petersburg State Pediatric Medical University, Ministry of Health of Russia
Russian Federation
Russian Federation
Dr. of Sci. (Med.), Professor, Head of the Department of Infectious Diseases in Children named after professor M.G. Danilevich. SPIN-code: 8594-0751
2 Litovskaya St., S.-Petersburg, 194100
V. A. Reznik
Saint-Petersburg State Pediatric Medical University, Ministry of Health of Russia
Russian Federation
Russian Federation
Cand. of Sci. (Med.), Chief Physician of the Clinic. SPIN-code: 9761-6624
2 Litovskaya St., S.-Petersburg, 194100
References
1. Uskov A.N., Lobzin Y.V., Rychkova S.V., Babachenko I.V., Fedorov V.V., Ulukhanova L.U., Pochinyaeva L.M. Course of a new coronavirus infection in children: some aspects of monitoring and analysis of mortality. Zhurnal infektologii = Journal of Infectology. 2020;12(3):12–20. (In Russ.) doi: 10.22625/2072-6732-2020-12-3-12-20.
2. Ivanov D.O., Petrenko Yu.V., Reznik V.A., Nasyrov R.A., Timchenko V.N., Subbotina M.D., Chernova T.M., Bannova S.L., Kondratyev G.V., Krasnogorskaya O.L., Paneyakh M.B., Fedotova E.P., Kaplina T.A., Shakmaeva M.A. Characteristics of new coronavirus infection in patients with acute myeloid leukemia. Voprosy prakticheskoy pediatrii = Clinical Practice in Pediatrics. 2021;16(3):121–9. (In Russ.) doi: 10.20953/1817-7646-2021-3-121-129.
3. Ivanov D.O., Chernova T.M., Pavlova E.B., Timchenko V.N., Barakina E.V. Coronavirus infection. Pediatr = Pediatrician. 2020;11(3):109–17. (In Russ.) doi: 10.17816/PED113109-117.
4. Leidman E., Duca L.M., Omura J.D., Proia K., Stephens J.W., Sauber-Schatz E.K. COVID-19 Trends Among Persons Aged 0–24 Years – United States, March 1–December 12, 2020. MMWR Morb Mortal Wkly Rep. 2021;70:88–94. doi: 10.15585/mmwr.mm7003e1.
5. Ludvigsson J.F. Systematic review of COVID-19 in children shows milder cases and a better prognosis than adults. Acta Paediatr. 2020;109:1088–95. doi: 10.1111/apa.15270.
6. Zimmermann P., Curtis N. Why is COVID-19 less severe in children? A review of the proposed mechanisms underlying the age-related difference in severity of SARS-CoV-2 infections. Arch Dis Child. 2020;archdischild-2020-320338. doi: 10.1136/archdischild-2020-320338.
7. Kosmeri C., Koumpis E., Tsabouri S., Siomou E., Makis A. Hematological manifestations of SARS-CoV-2 in children. Pediatr Blood Cancer. 2020;67:e28745. doi: 10.1002/pbc.28745.
8. Jain A., Chaurasia R., Sengar N.S., Singh M., Mahor S., Narain S. Analysis of vitamin D level among asymptomatic and critically ill COVID-19 patients and its correlation with inflammatory markers. Sci Rep. 2020;10(1):20191. doi: 10.1038/s41598-020-77093-z.
9. Raba A.A., Abobaker A., Elgenaidi I.S., Daoud A. Novel coronavirus infection (COVID-19) in children younger than one year: A systematic review of symptoms, management and outcomes. Acta Paediatr. 2020;109:1948–55. doi: 10.1111/apa.15422.
10. Dong Y., Mo X., Hu Y., Qi X., Jiang F., Jiang Z., Tong S. Epidemiology of COVID-19 Among Children in China. Pediatrics. 2020;145(6):e20200702. doi: 10.1542/peds.2020-0702.
11. Minotti C., Tirelli F., Barbieri E., Giaquinto C., Donà D. How is immunosuppressive status affecting children and adults in SARS-CoV-2 infection? A systematic review. Journal of Infection. 2020;81(1):61–6. doi: 10.1016/j.jinf.2020.04.026.
12. Nicastro E., Verdoni L., Bettini L.R., Zuin G., Balduzzi A., Montini G., Biondi A., D’Antiga L. COVID-19 in Immunosuppressed Children. Front Pediatr. 2021;9:629240. doi: 10.3389/fped.2021.629240.
13. Bresters D., Reus A.C.W., Veerman A.J.P., Van Wering E.R., Van Der Does-van den Berg A., Kaspers G.J.L. Congenital leukaemia: the Dutch experience and review of the literature. Brit J Haematol. 2002;117:513–24. doi: 10.1046/j.1365-2141.2002.03459.x.
14. Roberts I., Fordham N.J., Rao A., Bain B.J. Neonatal leukaemia. Br J Haematol. 2018;182:170–84. doi: 10.1111/bjh.15246.
15. Zhang Q., Ren Z., Yang J., Yin A. Analysis of 59 cases of congenital leukemia reported between 2001 and 2016. J Int Med Res. 2019;47(10):4625–35. doi: 10.1177/0300060519872899.
16. Van der Linden M.H., Creemers S., Pieters R. Diagnosis and management of neonatal leukaemia. Sem Fetal Neonatal Med. 2012;17(4):192–5. doi: 10.1016/j.siny.2012.03.003.
17. Balgobind B., Zwaan C., Pieters R., Van den Heuvel-Eibrink M.M. The heterogeneity of pediatric MLL-rearranged acute myeloid leukemia. Leukemia. 2011;25:1239–48. doi: 10.1038/leu.2011.90.
18. Chessells J., Harrison C., Kempski H., Webb D.K.H., Wheatley K., Hann I.M., Stevens R.F., Harrison G., Gibson B.E., MRC Childhood Leukaemia working party. Clinical features, cytogenetics and outcome in acute lymphoblastic and myeloid leukaemia of infancy: report from the MRC Childhood Leukaemia working party. Leukemia. 2002;16(5):776–84. doi: 10.1038/sj.leu.2402468.
19. Zweidler-McKay P.A., Hilden J.M. The ABCs of infant leukemia. Curr Probl Pediatr Adolesc Health Care. 2008;38(3):78–94. doi: 10.1016/j.cppeds.2007.12.001.
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For citations:
Ivanov D.O., Kondratiev G.V., Melnikov M.E., Bannova S.L., Kuleva S.A., Petrenko Yu.V., Timchenko V.N., Reznik V.A. Clinical case of long-term persistence of SARS-CoV-2 in infant with congenital acute myeloid leukemia. Russian Journal of Pediatric Hematology and Oncology. 2022;9(3):99-106. (In Russ.) https://doi.org/10.21682/2311-1267-2022-9-3-99-106
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