Orbital impairment in the debut of oncohematological diseases in children

   Tumor lesion of the orbit is found in the clinic of various oncohematological diseases in children. Untimely referral of such patients to an oncologist delays the timing of the necessary treatment, thereby worsening the prognosis of the disease. The literature review presents the features of clinical manifestations of orbital pathology in children at the onset of acute myeloid leukemia, myeloid sarcoma, lymphoma, Langerhans cell and non-Langerhans cell histiocytosis. The article presents our own observations and identifies factors that negatively affect the timely diagnosis of oncohematological diseases in this category of patients.

1. Brovkina A. F., Valsky V. V., Gusev G. A. Ophthalmooncology: A guide for physicians. Ed. A. F. Brovkina. M: Medicine, 2002. 331 p. (In Russ.)

2. Conneely M. F., Mafee M. F. Orbital rhabdomyosarcoma and simulating lesions. Neuroimaging Clin N Am. 2005;15: 121–36. doi: 10.1016/j.nic.2005.02.006.

3. Valiev T. T., Kovrigina A. M., Panferova T. R., Ushakova T. L., Serebryakova I. N., Tupitsyn N. N., Grivtsova L. Yu., Matveeva I. I., Mikhailova E. V., Popa A. V., Mentkevich G. L. A case report of myeloid sarcoma in a child. Klinicheskaya onkogematologiya. Fundamental’nyye issledovaniya i klinicheskaya praktika = Clinical Oncohematology. Basic Research and Clinical Practice. 2017; 10 (2): 218–26. (In Russ.)

4. Russo V., Scott I. U., Querques G., Stella A., Barone A., Delle Noci N. Orbital and Ocular Manifestations of Acute Childhood Leukemia: Clinical and Statistical Analysis of 180 Patients. Eur J Ophthalmol. 2008; 18 (4): 619–23. doi: 10.1177/112067210801800420.

5. Kiratli H., Demiroğlu H., Emeç S. Ocular relapse in acute myeloid leukemia (M4) with normal bone marrow. Int Ophthalmol. 2009; 29 (4): 243–5. doi: 10.1007/s10792-008-9207-5.

6. Sathitsamitphong L., Natesirinilkul R., Choeyprasert W., Charoenkwan P. Unusual Presentation with Orbital Mass in a Child with Precursor B-Cell Acute Lymphoblastic Leukemia. Case Rep Hematol. 2019; 2019: 8264689. doi: 10.1155/2019/8264689.

7. Ramamoorthy J., Jain R., Trehan A., Saxena A. K., Ahluwalia J. Orbital Mass in a Child With Acute Lymphoblastic Leukemia: A Case Report and Review of the Literature. J Pediatr Hematol Oncol. 2016; 38 (8): 646–8. doi:10.1097/MPH.0000000000000544.

8. Shields J. A., Shields C. L., Scartozzi R. Survey of 1264 patients with orbital tumors and simulating lesions: The 2002 Montgomery Lecture, part 1. Ophthalmology. 2004; 111 (5): 997–1008. doi: 10.1016/j.ophtha.2003.01.002.

9. Hossain I. T., Moosajee M., Abou-Rayyah Y., Pavasovic V. Orbital mass secondary to infantile acute lymphoblastic leukaemia. BMJ Case Rep. 2016; 2016: bcr2016214872. doi: 10.1136/bcr-2016-214872.

10. Thakker M. M., Rubin P. A., Chang E. Pre-B-cell acute lymphoblastic leukemia presenting as an orbital mass in an 8-month-old. Ophthalmology. 2006; 113 (2): 343–6. doi: 10.1016/j.ophtha.2005.10.016.

11. Chistyakova N. V. Ophthalmic manifestation of leukemia. Oftal’mologicheskiye vedomosti = Ophthalmology Journal. 2016; 9 (2): 81–99. (In Russ.)

12. Stockl F. A., Dolmetsch A. M., Saornil M. A. Orbital granulocytic sarcoma. Br J Ophthalmol. 1997; 81: 1084–8. doi: 10.1136/bjo.81.12.1084.

13. Fonseca A., Scheinemann K., Jansen J. Testicular myeloid sarcoma. J Pediatr Hematol Oncol. 2014; 36 (3): e155–7. doi: 10.1097/MPH.0000000000000097.

14. Bidar M., Wilson M. W., Laquis S. J., Wilson T. D., Fleming J. C., Wesley R. E., Ribeiro R. C., Haik B. G. Clinical and Imaging Characteristics of Orbital Leukemic Tumors. Ophthalmic Plast Reconstr Surg. 2007; 23 (2): 87–93. doi: 10.1097/IOP.0b013e3180333a85.

15. Zimmerman L. E., Font R. L. Ophthalmic manifestations of granulocytic sarcoma (myeloid sarcoma or chloroma). The Third Pan American Association of Ophthalmology and Journal of Ophthalmology Lecture. Am J Ophthalmol. 1975; 80: 975–90. doi: 10.1016/0002-9394(75)90326-8.

16. Murthy R., Vemuganti G. K., Honavar S. G., Naik M., Reddy V. Extramedullary leukemia in children presenting with proptosis. Hematol Oncol. 2009; 2: 4. doi: 10.1186/1756-8722-2-4.

17. Dravitsa L. V., Biryukov F. I., Hussein A., Zhadan M. N. T-cell lymphoma of the orbit (clinical case). Oftal’mologiya v Belarusi = Ophthalmology in Belarus. 2010; 2: 64–72. (In Russ.)

18. McCarten K. M., Nadel H. R., Shulkin B. L., Cho S. Y. Imaging for diagnosis, staging and response assessment of Hodgkin lymphoma and non-Hodgkin lymphoma. Pediatr Radiol. 2019; 49 (11): 1545–64. doi: 10.1007/s00247-019-04529-8.

19. Rao A. A., Naheedy J. H., Chen J. Y. Y., Robbins S. L., Ramkumar H. L. Review Article A Clinical Update and Radiologic Review of Pediatric Orbital and Ocular Tumors. J Oncol. 2013; 2013: 975908. doi: 10.1155/2013/975908.

20. Tőrők-Vistai T., Bojan A., Cucuianu A., Zsoldos A. Primary non-Hodgkin lymphoma of the orbit presenting with massive bilateral periorbital tumors. Clujul Med. 2013; 86 (4): 380–2. PMID: 26527983.

21. Li E. Y., Yuen H. K., Cheuk W. Lymphoproliferative Disease of the Orbit. Asia Pac J Ophthalmol (Phila). 2015; 4 (2): 106–11. doi: 10.1097/APO.0000000000000102.

22. Gupta R., Yadav J. S., Yadav S., Wadood A. Orbital Involvement in Nonendemic Burkitts Lymphoma. Orbit. 2012; 31 (6): 441–5. doi: 10.3109/01676830.2012.711886.

23. Sun L., Friedman A. H., Rodgers R., Schear M., Greaves G., Freidl K. B. T-cell lymphoblastic lymphoma involving the ocular adnexa: report of two cases and review of the current literature. Orbit. 2018; 38 (5): 412–8. doi: 10.1080/01676830.2018.1540013.

24. Faridpooya K., Mulder M. M. S., Merks J. H. M., de Smet M. D., Pals S. T., Saeed P. Precursor B Lymphoblastic Lymphoma of the Orbit in a Child: An Unusual Presentation of a Non-Hodgkin Lymphoma. Orbit. 2016; 25 (2): 153–7. doi: 10.1080/01676830600575501.

25. Parikh Vishal S., Jagadeesh D., Fernandez J. M., Hsi E. D., Singh A. D. Orbital diffuse large B-cell lymphoma with combined variable immunodefi ciency. Orbit. 2017; 36 (5): 340–3. doi: 10.1080/01676830.2017.1337170.

26. Olsen T. G., Heegaard S. Orbital Lymphoma. Surv Ophthalmol. 2019; 64 (1): 45–66. doi: 10.1016/j.survophthal.2018.08.002.

27. Gurieva O. D., Valiev T. T., Pavlovskaya A. I. Histiocytic neoplasms: modern aspects of pathogenesis, classification, diagnosis and treatment. Onkogematologiya = Oncohematology. 2021; 17 (1): 10–25. (In Russ.)

28. Dhar S., Srinivas S. M., Dhar S., Basu S., Banerjee R., Malakar R., Ghosh A., Bhattacharya A., Ray S. K., Bhattacharya A., Chowdhury J. Langerhans cell histiocytosis in children: A retrospective case series of 126 cases. Pediatr Dermatol. 2020; 37 (6): 1085–9. doi: 10.1111/pde.14389.

29. Laman J. D., Leenen P. J., Annels N. E., Hogendoorn P. C., Egeler R. M. Langerhans-cell histiocytosis 'insight into DC biology'. Trends Immunol. 2003; 24 (4): 190–6. doi: 10.1016/s1471-4906(03)00063-2.

30. Das J. K., Soibam R., Tiwary B. K., Magdalene D., Paul S. B., Bhuyan C. Orbital manifestations of Langerhans Cell Histiocytosis: A report of three cases. Oman J Ophthalmol. 2009; 2 (3): 137–40. doi: 10.4103/0974-620X.57315.

31. Herwig M. C., Wojno T., Zhang Q., Grossniklaus H. E. Langerhans cell histiocytosis of the orbit: five clinicopathologic cases and review of the literature. Surv Ophthalmol. 2013; 58 (4): 330–40. doi: 10.1016/j.survophthal.2012.09.004.

32. Zhou X. D., Song G. X., He Y. J. Clinical analysis of orbital histocytosis X. Zhonghua Yan Ke Za Zhi. 2003; 39 (11): 673–7. PMID: 14766063.

33. Pilguy E. I., Rovenskaya Y. V., Gevorkyan A. K., Aslamazyan L. K., Ermilova G. V., Menchshikova G. V. Cases of Disseminated and Giant Juvenile Xanthogranuloma in Children. Pediatricheskaya farmakologiya = Pediatric Pharmacology. 2014; 11 (6): 80–2. (In Russ.)

34. Kontos G., Borooah S., Khan A., Fleck B. W., Coupland S. E. The epidemiology, clinical characteristics, histopathology and management of juvenile- and adult-onset corneoscleral limbus xanthogranuloma. Graefes Arch Clin Exp Ophthalmol. 2016; 254 (3): 413–20. doi: 10.1007/s00417-015-3261-2.

35. Yarovoy A. A., Golubeva O. V., Kleyankina S. S., Yanchenko T. V. Juvenile xanthogranuloma of the eye. Vestnik oftal’mologii = Bulletin of Ophthalmology. 2018; 134 (1): 89–96. (In Russ.)

36. Mencía-Gutiérrez E., Gutiérrez-Diaz E., Madero-García S. Juvenile Xanthogranuloma of the Orbit in an Adult. Ophthalmologica. 2000; 214 (6): 437–40. doi: 10.1159/000027540.

37. Chidambaram B., Santosh V. Giant orbital and intracranial xanthogranuloma – a short report. Neurol India. 2001; 49 (2): 208–10. PMID: 11447452.

38. Daien V., Malrieueliaou C., Rodiere M., Rivier F., Dufier J. L., Villain M. Juvenile xanthogranuloma with bilateral optic neuritis. Br J Ophthalmol. 2011; 95 (9): 1331–2. doi: 10.1136/bjo.2009.171421.

39. Nemirovchenko V. S., Shervashidze M. A., Valiev T. T., Kondratchik K. L. Treatment results of pediatric acute myeloid leukemia with epigenetic drugs addition. Onkogematologiya = Oncohematology. 2020; 15 (2): 19–28. (In Russ.)

40. Valiev T. T. Burkitt lymphoma in children: 30 year treatment expirience. Pediatriya. Zhurnal im. G. N. Speranskogo = Pediatria. Journal named after G. N. Speransky. 2020; 99 (4): 35–42. (In Russ.)

41. Totadri S., Bansal D., Trehan A., Srinivasan R., Varma N., Kakkar N., Saxena A. K., Bhatia P. The 5-Year EFS of Multisystem LCH With Risk-Organ Involvement Is Suboptimal: A Single-center Experience From India. J Pediatr Hematol Oncol. 2016; 38 (1): e1–5. doi: 10.1097/MPH.0000000000000414.

42. Malakhova A. A., Mikhailova S. N., Ushakova T. L., Polyakov V. G. Determinants of late diagnosis and treatment of children with retinoblastoma. Analytical review of the organizational and methodological department of the Research Institute of Pediatric Oncology and Hematology at N. N. Blokhin National Medical Research Centre of Oncology, Ministry of Health of Russia. Rossiyskiy zhurnal detskoy gematologii i onkologii = Russian Journal of Pediatric Hematology and Oncology. 2021; 8 (4): 20–30. (In Russ.)