Acne disease in germ cell tumors. A brief review of the literature and a description of our own clinical observation
D. V. Martynov,
Т. S. Belysheva,
Т. Т. Valiev,
O. A. Kapkova,
E. V. Sharapova,
A. A. Prokofyev,
Ya. V. Vishnevskaya,
E. V. Mikhailova,
T. R. Panferova,
S. R. Varfolomeeva https://doi.org/10.21682/2311-1267-2023-10-1-73-80
Abstract
malignant neoplasms (MNP). The frequency of PNS in MNP ranges from 1 to 20 % according to different authors. One of the manifestations of PNS is acne, which occurs against the background of malignant neoplasm due to hormonal disorders.
The presented article describes a clinical case of a patient with a mixed germ cell tumor and metastases in the retroperitoneal lymph nodes. The germ cell tumor produced human beta-chorionic gonadotropin, which led to the development of acne as a PNS.
Antitumor treatment (surgical removal of the tumor and polychemotherapy) normalized the levels of human beta-chorionic gonadotropin and serum testosterone, which in turn led to regression of acne without acne therapy.
About the Authors
D. V. Martynov
N.N. Blokhin National Medical Research Centre of Oncology, Ministry of Health of Russia
Russian Federation
Russian Federation
first-year Resident Doctor in the specialty “Pediatric Oncology” of the Research Institute of Pediatric Oncology and Hematology named after Academician of the Russian Academy of Medical Sciences L.A. Durnov
23 Kashirskoe Shosse, Moscow, 115522
Т. S. Belysheva
N.N. Blokhin National Medical Research Centre of Oncology, Ministry of Health of Russia
Russian Federation
Russian Federation
Dr. of Sci. (Med.), Leading Researcher Scientific Advisory Division of the Research Institute of Pediatric Oncology and Hematology named after Academician of the Russian Academy of Medical Sciences L.A. Durnov
23 Kashirskoe Shosse, Moscow, 115522
Т. Т. Valiev
N.N. Blokhin National Medical Research Centre of Oncology, Ministry of Health of Russia
Russian Federation
Russian Federation
Dr. of Sci. (Med.), Head of the Department of Pediatric Oncology and Hematology (Chemotherapy of Hemoblastosis) No. 1 Research Institute of Pediatric Oncology and Hematology named after Academician of the Russian Academy of Medical Sciences L.A. Durnov
23 Kashirskoe Shosse, Moscow, 115522
O. A. Kapkova
N.N. Blokhin National Medical Research Centre of Oncology, Ministry of Health of Russia
Russian Federation
Russian Federation
Pediatric Oncologist Pediatric Oncology Department of Surgical Methods of Treatment with Chemotherapy No. 4 (Early Childhood) of the Research Institute of Pediatric Oncology and Hematology named after Academician of the Russian Academy of Medical Sciences L.A. Durnov
23 Kashirskoe Shosse, Moscow, 115522
E. V. Sharapova
N.N. Blokhin National Medical Research Centre of Oncology, Ministry of Health of Russia
Russian Federation
Russian Federation
Pediatric Oncologist Scientific Advisory Department Research Institute of Pediatric Oncology and Hematology named after Academician of the Russian Academy of Medical Sciences L.A. Durnov
23 Kashirskoe Shosse, Moscow, 115522
A. A. Prokofyev
“Dermatology Center Petrovka 15”
Russian Federation
Russian Federation
Bld. 5, 15/13 Petrovka St., Moscow,107031
Ya. V. Vishnevskaya
N.N. Blokhin National Medical Research Centre of Oncology, Ministry of Health of Russia
Russian Federation
Russian Federation
Cand. of Sci. (Med.), Pathologist Pathology Department Research Institute of Clinical Oncology named after N.N. Trapeznikov
23 Kashirskoe Shosse, Moscow, 115522
E. V. Mikhailova
N.N. Blokhin National Medical Research Centre of Oncology, Ministry of Health of Russia
Russian Federation
Russian Federation
Cand. of Sci. (Med.), Head of the Department of Radiology of the Department of Radiation Methods for the Diagnosis and Treatment of Tumors of the Research Institute of Pediatric Oncology and Hematology named after Academician of the Russian Academy of Medical Sciences L.A. Durnov
23 Kashirskoe Shosse, Moscow, 115522
T. R. Panferova
N.N. Blokhin National Medical Research Centre of Oncology, Ministry of Health of Russia
Russian Federation
Russian Federation
Cand. of Sci. (Med.), Senior Researcher of the Department of Radiology of the Department of Radiation Methods for the Diagnosis and Treatment of Tumors of the Research Institute of Pediatric Oncology and Hematology named after Academician of the Russian Academy of Medical Sciences L.A. Durnov
23 Kashirskoe Shosse, Moscow, 115522
S. R. Varfolomeeva
N.N. Blokhin National Medical Research Centre of Oncology, Ministry of Health of Russia
Russian Federation
Russian Federation
Dr. of Sci. (Med.), Professor, Director of the Research Institute of Pediatric Oncology and Hematology named after Academician of the Russian Academy of Medical Sciences L.A. Durnov
23 Kashirskoe Shosse, Moscow, 115522
References
1. Schneider D.T., Calaminus G., Göbel U. Diagnostic value of alpha 1-fetoprotein and beta-human chorionic gonadotropin in infancy and childhood. Pediatr Hematol Oncol. 2001;18(1):11–26. doi: 10.1080/088800101750059828.
2. Maeyama T., Ichikawa C., Okada Y. Beta-human chorionic gonadotropin-producing neuroblastoma: an unrecognized cause of gonadotropin-independent precocious puberty. Endocr J. 2022;69(3):313–8. doi: 10.1507/endocrj.EJ21-0366.
3. Onyema M.C., Drakou E.E., Dimitriadis G.K. Endocrine abnormality in paraneoplastic syndrome. Best Pract Res Clin Endocrinol Metab. 2022;36(3):101621. doi: 10.1016/j.beem.2022.101621.
4. Williams H.C., Dellavalle R.P., Garner S. Acne vulgaris. Lancet. 2012;379(9813):361–72. doi: 10.1016/S0140-6736(11)60321-8.
5. Elsaie M.L. Hormonal treatment of acne vulgaris: an update. Clin Cosmet Investig Dermatol. 2016;9:241–8. doi: 10.2147/CCID.S114830.
6. Yeung H., Kahn B., Ly B.C. Dermatologic Conditions in Transgender Populations. Endocrinol Metab Clin North Am. 2019;48(2):429–40. doi: 10.1016/j.ecl.2019.01.005.
7. Chen W., Thiboutot D., Zouboulis C.C. Cutaneous androgen metabolism: basic research and clinical perspectives. J Invest Dermatol. 2002;119(5):992–1007. doi: 10.1046/j.1523-1747.2002.00613.x.
8. Gollnick H.P. From new findings in acne pathogenesis to new approaches in treatment. J Eur Acad Dermatol Venereol. 2015;29 Suppl. 5:1–7. doi: 10.1111/jdv.13186.
9. Shaikh F., Murray M.J., Amatruda J.F. Paediatric extracranial germcell tumours. Lancet Oncol. 2016;17(4):e149–62. doi: 10.1016/S1470-2045(15)00545-8.
10. Dubey D., Kryzer T., Guo Y. Leucine Zipper 4 Autoantibody: A Novel Germ Cell Tumor and Paraneoplastic Biomarker. Ann Neurol. 2021;89(5):1001–10. doi: 10.1002/ana.26050.
11. Mercolini F., Battisti L., Sainati L. Paraneoplastic Cytopenia in Ovarian Germ Cell Tumor: A Novel Presentation. J Pediatr Hematol Oncol. 2018;40(7):e432–4. doi: 10.1097/MPH.0000000000001057.
12. Shindo K., Tsuchiya M., Koh K. Paraneoplastic sensorimotor neuropathy associated with mediastinal germ cell tumor: favorable outcome after high-dose intravenous immunoglobulin therapy. Neurol Sci. 2020;41(3):723–5. doi: 10.1007/s10072-019-04078-w.
13. Dimitriadis G.K., Kaltsas G., Ghobara T. Hypertestosteronemia and Infertility from a Mediastinal Extragonadal Germ Cell Tumor. Am J Med. 2017;130(6):e261–3. doi: 10.1016/j.amjmed.2017.01.010.
14. DeLellis R.A., Xia L. Paraneoplastic endocrine syndromes: a review. Endocr Pathol. 2003;14(4):303–17. doi: 10.1385/ep:14:4:303.
15. Oshrine B.R., Sullivan L.M., Balamuth N.J. Ectopic production of β-hCG by osteosarcoma: a case report and review of the literature. J Pediatr Hematol Oncol. 2014;36(3):e202–6. doi: 10.1097/MPH.0000000000000037.
16. Wong Y.P., Tan G.C., Aziz S. Beta-human Chorionic Gonadotropinsecreting Lung Adenocarcinoma. Malays J Med Sci. 2015;22(4):76–80. PMID: 26715912.
17. Scholl P.D., Jurco S., Austin J.R. Ectopic production of beta-HCG by a maxillary squamous cell carcinoma. Head Neck. 1997;19(8):701–5. doi: 10.1002/(sici)1097-0347(199712)19:8<701::aid-hed8>3.0.co;2-9.
18. Sato S., Nishizuka M., Asano M. RNA interference-mediated knockdown of the mouse gene encoding potassium channel subfamily K member 10 inhibits hormone-induced differentiation of 3T3-L1 preadipocytes. Comp Biochem Physiol B Biochem Mol Biol. 2010;157(1):46–53. doi: 10.1016/j.cbpb.2010.04.015.
19. Forst T., Beyer J., Cordes U. Gynaecomastia in a patient with a hCG producing giant cell carcinoma of the lung. Case report. Exp Clin Endocrinol Diabetes. 1995;103(1):28–32. doi: 10.1055/s-0029-1211326.
20. Dimitriadis G.K., Angelousi A., Weickert M.O. Paraneoplastic endocrine syndromes. Endocr Relat Cancer. 2017;24(6):R173–90. doi: 10.1530/ERC-17-0036.
Review
For citations:
Martynov D.V., Belysheva Т.S., Valiev Т.Т., Kapkova O.A., Sharapova E.V., Prokofyev A.A., Vishnevskaya Ya.V., Mikhailova E.V., Panferova T.R., Varfolomeeva S.R. Acne disease in germ cell tumors. A brief review of the literature and a description of our own clinical observation. Russian Journal of Pediatric Hematology and Oncology. 2023;10(1):73-80. (In Russ.) https://doi.org/10.21682/2311-1267-2023-10-1-73-80
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