Urothelial carcinoma of the bladder in a 10-year-old female patient: a case report and literature review
A. S. Fedorova,
V. A. Muradova,
A. M. Mitrofanova,
A. V. Tarakanova,
A. A. Semenov,
V. E. Sokolova,
D. M. Konovalov https://doi.org/10.21682/2311-1267-2025-12-4-83-88
Abstract
Urothelial carcinomas are extremely rare in pediatric patients. Unlike in adults, exogenous risk factors do not play a leading role in the development of this disease in children. This article presents a clinical case of urothelial bladder carcinoma with a relapsing course in a 10-year-old patient.
About the Authors
A. S. Fedorova
Russian Children’s Clinical Hospital – Branch of the N.I. Pirogov Russian National Research Medical University, Ministry of Health of Russia
Russian Federation
Russian Federation
Pathologist, Pathology Department
117 Leninskiy Prosp., Moscow, 117997
V. A. Muradova
Moscow Botkin Multidisciplinary Scientific and Clinical Center, Healthcare Department of the Government of Moscow
Russian Federation
Russian Federation
Pathologist, Pathology Department
5 2nd Botkinskiy Proyezd, Moscow, 125284
A. M. Mitrofanova
Dmitry Rogachev National Medical Research Center of Pediatric Hematology
Russian Federation
Russian Federation
Pathologist, Pathology Department
1 Samory Mashela St., Moscow, 117997
A. V. Tarakanova
Dmitry Rogachev National Medical Research Center of Pediatric Hematology
Russian Federation
Russian Federation
Pathologist, Pathology Department
1 Samory Mashela St., Moscow, 117997
A. A. Semenov
Lipetsk Regional Children’s Hospital
Russian Federation
Russian Federation
Pediatric Oncologist, Pediatric Surgeon, Acting Head of the Pediatric Oncology Department
6a Moskovskaya St., Lipetsk, 398042
V. E. Sokolova
Russian Children’s Clinical Hospital – Branch of the N.I. Pirogov Russian National Research Medical University, Ministry of Health of Russia
Russian Federation
Russian Federation
Head of the Pathology Department
117 Leninskiy Prosp., Moscow, 117997
D. M. Konovalov
Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology, Ministry of Health of Russia; Russian Medical Academy of Continuous Professional Education, Ministry of Health of Russia
Russian Federation
Russian Federation
Cand. of Sci. (Med.), Head of the Pathology Department; Associate Professor of the Department of Pathological Anatomy
1 Samory Mashela St., Moscow, 117997
Bldg. 1, 2/1 Barrikadnaya St., Moscow, 125993
References
1. Shakhzadova A.O., Starinsky V.V., Lisichnikova I.V. Cancer care to the population of Russia in 2022. Sibirskij onkologicheskij zhurnal = Siberian Journal of Oncology. 2023;22(5):5–13. (In Russ.)].
2. Siegel R.L., Giaquinto A.N., Ahmedin J. Cancer statistics, 2024. CA Cancer J Clin. 2024;74(1):12–49. doi: 10.3322/caac.21820.
3. Rykov M.Yu., Sevryukov D.D., Vilkova A.S. Malignant neoplasms in children: clinical manifestations and diagnosis. Voprosy sovremennoj pediatrii = Current Pediatrics. 2017;16(5):370–82. (In Russ.)].
4. Steliarova-Foucher E., Colombet M., Ries L.A.G., Moreno F., Dolya A., Bray F., Hesseling P., Shin H.Y., Stiller C.A.; IICC-3 contributors. International incidence of childhood cancer, 2001–10: a population-based registry study. Lancet Oncol. 2017;18(6):719–31. doi: 10.1016/S1470-2045(17)30186-9.
5. Gutierrez J.C., Housri N., Koniaris L.G., Fischer A.C., Sola J.E. Malignant breast cancer in children: a review of 75 patients. J Surg Res. 2008;147(2):182–8. doi: 10.1016/j.jss.2008.03.026.
6. Deepak J., Raj M., Brijesh L. Colorectal carcinoma in pediatric age group-epidemiological paradigm. Ann Oncol. 2014;25(Supple):ii95.
7. Balzer B.W.R., Loo C., Lewis C.R., Trahair T.N., Anazodo A.C. Adenocarcinoma of the lung in childhood and adolescence: a systematic review. J Thorac Oncol. 2018;13(12):1832–41. doi: 10.1016/j.jtho.2018.08.2020.
8. Sung H., Ferlay J., Siegel R.L., Laversanne M., Soerjomataram I., Jemal A., Bray F. Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2021;71(3):209–49. doi: 10.3322/caac.21660.
9. WHO Classifi cation of Tumours Editorial Board, editor. Urinary and Male Genital Tumours: WHO Classifi cation of Tumours, 5th Edition, Volume 8. Lyon (France): International Agency for Research on Cancer, 2022. 576 p.
10. Marinoni F., Destro F., Selvaggio G.G.O., Riccipetitoni G. Urothelial carcinoma in children: A case series. Bull Cancer. 2018;105(6):556–61. doi: 10.1016/j.bulcan.2018.03.002.
11. Erikson M.S., Petersen A.C., Andersen K.K., Andreasen A.H., Friis S., Mogensen K., Hermann G.G. National incidence and survival of patients with non-invasive papillary urothelial carcinoma: a Danish population study. Scand J Urol. 2018;52(5–6):364–70. doi: 10.1080/21681805.2018.1518926.
12. Saginala K., Barsouk A., Aluru J.S., Rawla P., Padala S.A., Barsouk A. Epidemiology of bladder cancer. Med Sci (Basel). 2020;8(1):15. doi: 10.3390/medsci8010015.
13. Rezaee M.E., Dunaway C.M., Baker M.L., Penna F.J., Chavez D.R. Urothelial cell carcinoma of the bladder in pediatric patients: a systematic review and data analysis of the world literature. J Pediatr Urol. 2019;15(4):309–14. doi: 10.1016/j.jpurol.2019.06.013.
14. Kamihara J., Bourdeaut F., Foulkes W.D., Molenaar J.J., Mossé Y.P., Nakagawara A., Parareda A., Scollon S.R., Schneider K.W., Skalet A.H., States L.J., Walsh M.F., Diller L.R., Brodeur G.M. Retinoblastoma and neuroblastoma predisposition and surveillance. Clin Cancer Res. 2017;23(13):e98–106. doi: 10.1158/1078-0432.CCR-17-0652.
15. Shelmerdine S.C., Lorenzo A.J., Gupta A.A., Chavhan G.B. Pearls and pitfalls in diagnosing pediatric urinary bladder masses. Radiographics. 2017;37(6):1872–91. doi: 10.1148/rg.2017170031.
16. Rifat U.N., Hamadalla N.Y., Chiad Safi K.C., Al Habash S.S., Mohammed M. Urothelial bladder tumour in childhood: A report of two cases and a review. Arab J Urol. 2015;13(2):116–21. doi: 10.1016/j.aju.2014.11.002.
17. Robertson A.G., Kim J., Al-Ahmadie H., Bellmunt J., Guo G., Cherniack A.D., Hinoue T., Laird P.W., Hoadley K.A., Akbani R., Castro M.A.A., Gibb E.A., Kanchi R.S., Gordenin D.A., Shukla S.A., Sanchez-Vega F., Hansel D.E., Czerniak B.A., Reuter V.E., Su X., de Sa Carvalho B., Chagas V.S., Mungall K.L., Sadeghi S., Pedamallu C.S., Lu Y., Klimczak L.J., Zhang J., Choo C., Ojesina A.I., Bullman S., Leraas K.M., Lichtenberg T.M., Wu C.J., Schultz N., Getz G., Meyerson M., Mills G.B., McConkey D.J.; TCGA Research Network; Weinstein J.N., Kwiatkowski D.J., Lerner S.P. Comprehensive molecular characterization of muscle-invasive bladder cancer. Cell. 2018;174(4):1033. doi: 10.1016/j.cell.2018.07.036.
18. Isharwal S., Audenet F., Drill E., Pietzak E.J., Iyer G., Ostrovnaya I., Cha E., Donahue T., Arcila M., Jayakumaran G., Berger M.F., Rosenberg J.E., Bajorin D.F., Coleman J., Dalbagni G., Reuter V.E., Bochner B.H., Solit D.B., Al-Ahmadie H.A. Prognostic value of TERT alterations, mutational and copy number alterations burden in urothelial carcinoma. Eur Urol Focus. 2019;5(2):201–4. doi: 10.1016/j.euf.2017.07.004.
19. Kinde I., Munari E., Faraj S.F., Hruban R.H., Schoenberg M., Bivalacqua T., Allaf M., Springer S., Wang Y., Diaz L.A. Jr, Kinzler K.W., Vogelstein B., Papadopoulos N., Netto G.J. TERT promoter mutations occur early in urothelial neoplasia and are biomarkers of early disease and disease recurrence in urine. Cancer Res. 2013;73(24):7162–7. doi: 10.1158/0008-5472.CAN-13-2498.
20. Pietzak E.J., Bagrodia A., Cha E.K., Drill E.N., Iyer G., Isharwal S., Ostrovnaya I., Baez P., Li Q., Berger M.F., Zehir A., Schultz N., Rosenberg J.E., Bajorin D.F., Dalbagni G., Al-Ahmadie H., Solit D.B., Bochner B.H. Next-generation sequencing of nonmuscle invasive bladder cancer reveals potential biomarkers and rational therapeutic targets. Eur Urol. 2017;72(6):952–9. doi: 10.1016/j.eururo.2017.05.032.
21. Hurst C.D., Knowles M.A. Mutational landscape of non-muscleinvasive bladder cancer. Urol Oncol. 2022;40(7):295–303. doi: 10.1016/j.urolonc.2018.10.015.
22. Pollard C., Smith S.C., Theodorescu D. Molecular genesis of nonmuscle-invasive urothelial carcinoma (NMIUC). Expert Rev Mol Med. 2010;12:e10. doi: 10.1017/S1462399410001407.
23. Aykan S., Yuruk E., Tuken M., Temiz M.Z., Ozsoy S. Rare but lethal disease of childhood: metastatic, muscle invasive bladder cancer. Pediatr Rep. 2015;7(3):5928. doi: 10.4081/pr.2015.5928.
24. Bianchi M., Roghmann F., Becker A., Sukumar S., Briganti A., Menon M., Karakiewicz P.I., Sun M., Noldus J., Trinh Q.D. Agestratifi ed distribution of metastatic sites in bladder cancer: A population-based analysis. Can Urol Assoc J. 2014;8(3–4):E148–58. doi: 10.5489/cuaj.787.
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For citations:
Fedorova A.S., Muradova V.A., Mitrofanova A.M., Tarakanova A.V., Semenov A.A., Sokolova V.E., Konovalov D.M. Urothelial carcinoma of the bladder in a 10-year-old female patient: a case report and literature review. Russian Journal of Pediatric Hematology and Oncology. 2025;12(4):83-88. (In Russ.) https://doi.org/10.21682/2311-1267-2025-12-4-83-88
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