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Russian Journal of Pediatric Hematology and Oncology

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Efficacy allogeneic hematopoietic stem cell transplantation with different conditioning regimens in pediatric myelodysplastic syndrome

https://doi.org/10.17650/2311-1267-2017-4-2-70-77

Abstract

Treatment results of hematopoietic stem cells transplantation (HSCT) with myeloablative (MAC) and reduced intensity (RIC) conditioning regimen in children and adolescents with myelodysplastic syndrome (MDS). Fifty seven patients aged 1to18 years who received allo-HSCT from 1996 to 2016 (30 patients with MAC and 29 patients with RIC) are included in the study. Analysis of overall and event-free survival in both groups showed comparable efficacy. The use of RIC as alternative conditioning regimen in children and adolescents with MDS.

About the Authors

A. A. Osipova
Raisa Gorbacheva Memorial Research Institute of Children Oncology, Hematology and Transplantation, First Pavlov State Medical University of St. Petersburg, Ministry of Health of Russia
Russian Federation
6–8 L’va Tolstogo St., Saint Petersburg, 197022


E. V. Semenova
Raisa Gorbacheva Memorial Research Institute of Children Oncology, Hematology and Transplantation, First Pavlov State Medical University of St. Petersburg, Ministry of Health of Russia
Russian Federation
6–8 L’va Tolstogo St., Saint Petersburg, 197022


E. V. Morozova
Raisa Gorbacheva Memorial Research Institute of Children Oncology, Hematology and Transplantation, First Pavlov State Medical University of St. Petersburg, Ministry of Health of Russia
Russian Federation
6–8 L’va Tolstogo St., Saint Petersburg, 197022


T. A. Bykova
Raisa Gorbacheva Memorial Research Institute of Children Oncology, Hematology and Transplantation, First Pavlov State Medical University of St. Petersburg, Ministry of Health of Russia
Russian Federation
6–8 L’va Tolstogo St., Saint Petersburg, 197022


V. N. Ovechkina
Raisa Gorbacheva Memorial Research Institute of Children Oncology, Hematology and Transplantation, First Pavlov State Medical University of St. Petersburg, Ministry of Health of Russia
Russian Federation
6–8 L’va Tolstogo St., Saint Petersburg, 197022


A. S. Borovkova
Raisa Gorbacheva Memorial Research Institute of Children Oncology, Hematology and Transplantation, First Pavlov State Medical University of St. Petersburg, Ministry of Health of Russia
Russian Federation
6–8 L’va Tolstogo St., Saint Petersburg, 197022


P. V. Kozhokar
Raisa Gorbacheva Memorial Research Institute of Children Oncology, Hematology and Transplantation, First Pavlov State Medical University of St. Petersburg, Ministry of Health of Russia
Russian Federation
6–8 L’va Tolstogo St., Saint Petersburg, 197022


O. V. Paina
Raisa Gorbacheva Memorial Research Institute of Children Oncology, Hematology and Transplantation, First Pavlov State Medical University of St. Petersburg, Ministry of Health of Russia
Russian Federation
6–8 L’va Tolstogo St., Saint Petersburg, 197022


S. V. Razumova
Raisa Gorbacheva Memorial Research Institute of Children Oncology, Hematology and Transplantation, First Pavlov State Medical University of St. Petersburg, Ministry of Health of Russia
Russian Federation
6–8 L’va Tolstogo St., Saint Petersburg, 197022


E. V. Babenko
Raisa Gorbacheva Memorial Research Institute of Children Oncology, Hematology and Transplantation, First Pavlov State Medical University of St. Petersburg, Ministry of Health of Russia
Russian Federation
6–8 L’va Tolstogo St., Saint Petersburg, 197022


A. L. Alyanskiy
Raisa Gorbacheva Memorial Research Institute of Children Oncology, Hematology and Transplantation, First Pavlov State Medical University of St. Petersburg, Ministry of Health of Russia
Russian Federation
6–8 L’va Tolstogo St., Saint Petersburg, 197022


T. L. Gindina
Raisa Gorbacheva Memorial Research Institute of Children Oncology, Hematology and Transplantation, First Pavlov State Medical University of St. Petersburg, Ministry of Health of Russia
Russian Federation
6–8 L’va Tolstogo St., Saint Petersburg, 197022


I. M. Barkhatov
Raisa Gorbacheva Memorial Research Institute of Children Oncology, Hematology and Transplantation, First Pavlov State Medical University of St. Petersburg, Ministry of Health of Russia
Russian Federation
6–8 L’va Tolstogo St., Saint Petersburg, 197022


B. I. Smirnov
Saint Petersburg State Electrotechnical University “LETI” named after V.I. Ulianov (Lenin) of the Ministry of education and partnership education and science of the Russian Federation
Russian Federation
5 Professor Popov St., Saint Petersburg, 197376


L. S. Zubarovskaya
Raisa Gorbacheva Memorial Research Institute of Children Oncology, Hematology and Transplantation, First Pavlov State Medical University of St. Petersburg, Ministry of Health of Russia
Russian Federation
6–8 L’va Tolstogo St., Saint Petersburg, 197022


B. V. Afanasiev

Russian Federation


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Review

For citations:


Osipova A.A., Semenova E.V., Morozova E.V., Bykova T.A., Ovechkina V.N., Borovkova A.S., Kozhokar P.V., Paina O.V., Razumova S.V., Babenko E.V., Alyanskiy A.L., Gindina T.L., Barkhatov I.M., Smirnov B.I., Zubarovskaya L.S., Afanasiev B.V. Efficacy allogeneic hematopoietic stem cell transplantation with different conditioning regimens in pediatric myelodysplastic syndrome. Russian Journal of Pediatric Hematology and Oncology. 2017;4(2):70-77. (In Russ.) https://doi.org/10.17650/2311-1267-2017-4-2-70-77

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ISSN 2311-1267 (Print)
ISSN 2413-5496 (Online)
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