Clinical case: allogeneic transplantation of hematopoietic stem cells for Fanconi anemia in the onset of refractory anemia with excess blasts
https://doi.org/10.21682/2311-1267-2022-9-4-114-118
Abstract
Fanconi anemia (AF) is a hereditary genetic disease characterized by developmental abnormalities, progressive bone marrow failure, hypersensitivity to alkylating agents, and a tendency to hematological and solid tumors throughout life. The only curative option in the treatment of bone marrow failure in patients with AF is allogeneic hematopoietic stem cell transplantation (allo-HSCT). There are no detailed descriptions of allo-HSCT in patients with AF in the Russian-language literature. On the example of a clinical case with AF at the onset of myelodysplastic syndrome, a choose of method for treating bone marrow failure is presented.
Keywords
Fanconi anemia,
hematopoietic stem cell transplantation,
allogeneic transplantation,
hematology,
refractory anemia with excess blasts
Supporting agencies: The study was performed without external funding
About the Authors
M. E. Prokofiev
N. N. Blokhin National Medical Research Centre of Oncology, Ministry of Health of Russia
Russian Federation
Russian Federation
Resident
Research Institute of Pediatric Oncology and Hematology
Department of Pediatric Oncology
115478
23 Kashirskoe Shosse
Moscow
I. O. Kostareva
N. N. Blokhin National Medical Research Centre of Oncology, Ministry of Health of Russia
Russian Federation
Russian Federation
Pediatric Oncologist
Research Institute of Pediatric Oncology and Hematology
Department of Pediatric Oncology and Hematology with a Bone Marrow Transplant Unit
115478
23 Kashirskoe Shosse
Moscow
K. A. Sergeenko
Russian Medical Academy of Continuous Professional Education, Ministry of Health of Russia
Russian Federation
Russian Federation
Resident
Department of Pediatric Oncology named after Academician L. A. Durnov
125993
Bld. 1, 2/1 Barrikadnaya St.
Moscow
N. G. Stepanyan
N. N. Blokhin National Medical Research Centre of Oncology, Ministry of Health of Russia
Russian Federation
Russian Federation
Transfusiologist
Research Institute of Pediatric Oncology and Hematology
Department of Pediatric Oncology and Hematology with a Bone Marrow Transplant Unit
115478
23 Kashirskoe Shosse
Moscow
N. V. Sidorova
N. I. Pirogov Russian National Research Medical University, Ministry of Health of Russia
Russian Federation
Russian Federation
Assistant
Faculty of Pediatrics
Department of Oncology, Hematology and Other Radiation Therapy
117997
1 Ostrovityanova
Moscow
K. I. Kirgizov
N. N. Blokhin National Medical Research Centre of Oncology, Ministry of Health of Russia
Russian Federation
Russian Federation
Cand. of Sci. (Med.), Deputy Director for Scientific and Educational Work
Research Institute of Pediatric Oncology and Hematology
115478
23 Kashirskoe Shosse
Moscow
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Review
For citations:
Prokofiev M.E., Kostareva I.O., Sergeenko K.A., Stepanyan N.G., Sidorova N.V., Kirgizov K.I. Clinical case: allogeneic transplantation of hematopoietic stem cells for Fanconi anemia in the onset of refractory anemia with excess blasts. Russian Journal of Pediatric Hematology and Oncology. 2022;9(4):114-118. (In Russ.) https://doi.org/10.21682/2311-1267-2022-9-4-114-118
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